Isoeugenol is a substituted phenol.
Function(s): Flavoring Agent; Fragrance Ingredient; Masking
Other names: 2-Methoxy-4- (1-Propenyl) - Phenol; 2-Methoxy-4- (1-Propenyl) Phenol; 4-Hydroxy-3-Methoxy-1-Propenylbenzene; 4-Propemylguaiacol; Phenol, 2-Methoxy-4- (1-Propenyl) -; Phenol, 2Methoxy4 (1Propenyl) ; 1-Hydroxy-2-Methoxy-4-Propenylbenzene; 2-Methoxy-4-Propenylphenol; 4-Hydroxy-3-Methoxy-1-Propenylbenzene; 4-Propenylguaiacol; Nci-C60979
Developmental & reproductive toxicity: ○○○○○○○○○○○○
Allergies & immunotoxicity:
Natural or synthetic?
What Is It?
Isoeugenol is a pale yellow liquid with a spicy, carnation-like odor. In cosmetics and personal care products, Isoeugenol is used in the formulation of perfumes, shaving products, and skin care products.
Why is it used in cosmetics and personal care products?
The Food and Drug Administration (FDA) has approved the use of Isoeugenol as a flavoring agent for direct addition to food. The safety of Isoeugenol has been evaluated by the Research Institute for Fragrance Materials Expert Panel (REXPAN). Based on this evaluation, an International Fragrance Association (IFRA) Standard has been established. The IFRA Standard restricts the use of Isoeugenol in fragrances because of potential sensitization.
Link to the IFRA Standards: http://www.ifraorg.org/en-us/standards_1
The Cosmetic Ingredient Review (CIR) defers review of individual fragrance ingredients to the IFRA program unless the ingredient has significant uses other than as a fragrance. In this case, the ingredient may be assessed by both the CIR Expert Panel and REXPAN.
More safety Information:
Link to FDA Code of Federal Regulations for Isoeugenol: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr...
The Joint FAO/WHO Expert Committee on Food Additives (JECFA) concluded that Isoeugenol does not present a safety concern at current levels of intake when used as a flavoring agent.
Link to the JECFA safety evaluation of Isoeugenol: http://www.inchem.org/documents/jecfa/jeceval/jec_1192.htm
The Flavor and Extract Manufacturers Association Expert Panel has reviewed the safety of Isoeugenol and determined that it was Generally Recognized as Safe for use as a flavoring substance. In Europe, Isoeugenol is included on the list of â€œallergenicâ€ substances. The European Cosmetics Directive requires manufacturers of cosmetics and personal care products to indicate the presence of certain "allergenic" substances in the list of ingredients if they are present above certain levels in the product (see Annex III).
The presence of Isoeugenol must be indicated in the list of ingredients when its concentration exceeds: 0.001% in leave-on the skin products 0.01% in products that are rinsed off the skin
Link to the EU Cosmetic Regulation: http://europa.eu/legislation_summaries/consumers/product_labelling_and_packaging/co0013_en.htm